Updated: May 4, 2020
PhD Studentship - HOPE: Automatic Detection of Seizure Onset Zone from EEG/MEG Signals in Children with MRE
Life and Health Sciences - Studentships
Location: Aston University Main Campus
Basis: Full Time
Closing Date: 23.59 hours BST on Tuesday 30 April 2019
Main Supervisor: Dr Manousos Klados;
Associate Supervisors: Professor Stefano Seri & Dr Antonio Fratini
Many patients with epileptic seizures are proven medically resistant and respective surgery is the only remaining treatment alternative. This is performed for removing a small portion of brain tissue that is currently defined using intracranial electroencephalogram (iEEG). To date, this results in a significant number of patients continuing to experience postsurgical seizures. During the last few years, high-frequency oscillations (HFOs above 80 Hz) have emerged as a new promising biomarker in pre-surgical diagnosis of epileptogenicity, while the resection of the tissue generating HFOs improves surgical outcome in patients with medically refractory epilepsy (MRE). The ultimate goal of the project is to automatically detect HFOs and localise their source of origin, by using only high-density EEG and/or MEG, which is necessary for a solid sampling and accurate localisation of HFOs on the scalp. The main outcomes of the project will be so, the gained knowledge for the mechanism of HFOs and their relation to epilepsy as a valuable tool for the clinicians who perform surgical operations, and patients who will refrain from invasive monitoring (iEEG).
The successful candidate will contribute to the development and testing of algorithms able to automatically detect HFOs. They will be working on the boarders of biomedical engineering and human neuroscience. This is a unique opportunity, since you will have the chance to work inside a multidisciplinary project funded by the EU, and visit project partners to gain more research knowledge and experience.
Aston University was ranked 5th out of 94 UK Higher Education Institutions for research in Allied Health Professions (REF 2014) and was ranked 1st for research environment. Additional information about research in the School can be found at http://www.aston.ac.uk/lhs/research/. Informal enquiries can be made to Dr Manousos Klados: firstname.lastname@example.org.
The studentship is open to Home/EU students only and comprises of a tax-free stipend at the 2018/19 RCUK rate of £14,777 p.a. and payment of Home/EU tuition fees only. The stu